Aging and Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Iron, Aging, and Neurodegeneration
Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the irreplaceable nature of neurons. In this regard regulation of brain iron chemistry is essential to m...
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Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of cellular dysfunctions and neuronal death. Howeve...
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ژورنال
عنوان ژورنال: Journal of Molecular and Genetic Medicine
سال: 2013
ISSN: 1747-0862
DOI: 10.4172/1747-0862.1000071